Leucanthemum vulgare is one of the most widespread weeds in the Anthemideae. It became an introduced species via gardens into natural areas in parts of Canada, the United States, Australia, and New Zealand. In some habitats it forms dense colonies displacing native plants and modifying existing communities.
Ox-eye daisy commonly invades lawns, and is difficult to control or eradicate, since a new plant can regenerate from rhizome fragments and is a problem in pastures where beef and dairy cattle graze, as usually they will not eat it, thus enabling it to spread; cows who do eat it produce milk with an undesirable flavor. It has been shown to carry several crop diseases.
This species has been declared an environmental weed in New South Wales and Victoria. In New South Wales it grows from Glen Innes on the Northern Tablelands to Bombala in the far southeast of the state, and there are significant populations in the Kosciuszko National Park where it has invaded subalpine grassland, snowgum (Eucalyptus pauciflora) woodland and wetlands. In Victoria it is a prohibited species and must be eradicated or controlled
